Lona is one of the people who was abducted and later reappeared with all the others. Lona is a professional assassin, working for the government to kill off people it feels are dangerous. Once she returns, though, she seems to be under someone else's basic control, and she begins to kill off people from her past.
It's up to NTAC to track her down and stop her, even though she now apparently possesses incredible powers of speed and time control. She even murders her lover. Still, a different 4400 has his own ability, and he aids NTAC in its quest to stop Lona.
It's a good book, true to the series, and a good indication that more 4400 books should be done.
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